ICSB 2008 Workshop: Systems Biology of the Liver

Topic:
The liver is the central detoxification organ and the only organ that is capable of regeneration. Several international consortia apply the Systems Biology approach to understand the complex behaviour of multiple aspects of liver biology. This interdisciplinary workshop brings together scientists from different fields - toxicology, biology, medicine, engineering, mathematics and physics - who will report their recent results in the fields of detoxification, regeneration, cell biology and signal transduction of liver cells. The perspectives of "Systems Biology of the Liver" includes personalized medicine, improved strategies for targeted intervention, rational tissue engineering, reduction of animal testing in drug development, and more efficient clinical testing.
Organizers, on behalf of the Project Committee of HepatoSys, the German Federal Ministry of Education and Research funding initiative for Systems Biology of the hepatocytes:
- Ursula Klingmüller, German Cancer Research Center, Heidelberg, Germany
- Jens Timmer, University of Freiburg, Germany
Location: Wallenberg Conference Center
Date: Wednesday, August 27, 2008, Starting time: 2:30 pm
Registration: For registration, please, send an informal e-mail to Jens Timmer.

REGISTRATION NO LONGER NEEDED: JUST COME ALONG AND JOIN US !
Fee: The participation is free of charge. Costs for catering will be covered from our side.
Programme
- 2:30 Anja Zeigerer, MPI Dresden, HepatoSys: "Systems biology analysis of the endocytic pathway in primary mouse hepatocytes"
- 2:50 Sebastian Bohl, German Cancer Research Center, HepatoSys: "Data-based analysis of network structures for regulation and adaptation of the gp130-JAK1-STAT3 signaling pathway in primary hepatocytes"
- 3:10 Leonidas Alexopoulos, National Technical University of Athens, Greece: "Context specific pathway maps of normal and cancer hepatocytes using high-throughput phosphoprotein measurements "
- 3:30 Julio Saez-Rodriguez, MIT: Interrogation of the topology of signaling networks with large-scale data within a Boolean framework uncovers mechanistic differences between primary and cancerous hepatocytes"
- 3:50 Jan Hoek, Jefferson University, USA: "Characterizing the EGFR signaling network in hepatocytes"
- 4:10 - 4:40 Coffee break
- 4:40 Jan Hengstler, Dirk Drasdo: "Liver regeneration: mathematical models give insights into spatial-temporal alteration of tissue architecture and identify the responsible key factors"
- 5:00 Imran Shah, The Virtual Liver Project, USA: "The Virtual Liver Project: Simulating Tissue Injury through Molecular and Cellular Processes"
- 5:20 Igor Goryanin, BBSRC Centre for Systems Biology, Edinburgh: "Systems Kinetic Modelling for Pharmaceutical Industry"
- 5:40 Christian Bölling, Charite, Berlin, HepatoSys: "HepatoNet - network reconstruction, metabolic model and knowledgebase of human hepatocytes"
- 6:00 - 6:30 Coffee break
- 6:30 Jens Reich, Max Delbrück Centre, Berlin, HepatoSys: "Liver as a Regulator of Iron Uptake and Iron Detoxification: Molecular Control and Systemic Integration in Physiological and Pathological Function. A Kinetic Model of Time and Pool Hierarchy"
- 6:50 Matthias Reuss, University of Stuttgart, HepatoSys: A quantitative understanding of dynamic cellular processes during detoxification in human hepatocytes
- 7:10 Damjana Rozman, Steroltalk, University of Ljubljana, EU FP7 STEROLTALK: The Steroltalk microarray: a systemic approach to studies of cholesterol homeostasis and drug metabolism"
- 7:30 All speakers and participants: Discussion of joint future projects and possibilities of funding
Participants:
- Anja Schoettler, UKE Hamburg, Germany
- Yong-Jun Shin, University of Texas at Dallas, USA
- Martin Adiels, Gothenburg University, Sweden
- Bogdan Tokovenko, Institute of Molecular Biology and Genetics, Kyiv, Ukraine
- Murle Scrutchin, Entelos, USA
- Mikko Hellgren, Karolinska Institutet, Sweden
- Torbjörn Nordling, Royal Institute of Technology, Stockholm, Sweden
- Alaa Othman, Bremen University, German
- Martin Berglund, Gothenburg University, Sweden
- Bernt Wennberg, Chalmers, Gothenburg, Sweden
- Hongwu Ma, University of Edinburgh, Scotland
- Hans Westerhoff, Amsterdam, The Netherlands & Manchester, U.K.
- Katrin Fundel, Boehringer Ingelheim Pharma, Germany
- Sven Nahnsen, Uni Tübingen, Germany
- Oliver Frey, Charité, Berlin
- Mohammed Isam Atari, University of Warwick, U.K.
- Mohammad Ali Malboobi, NIGEB, Tehran, Iran
- Steffen Klamt, MPI Magdeburg, Germany
- Edyta Bajak, Uppsala University, Sweden
- Ruslan Sharipov, Novosibirsk, Russia
- Fernando Ortega, AstraZeneca, U.K.
- Stefan Höhme, University of Leipzig, Germany
- Regina Samaga, MPI Magdeburg, Germany
- Maria Athelogou, Definiens, Munich, Germany
- Anja Thormann, FU Berlin, Germany
- Johannes Bausch, University Freiburg, Germany
- Ramona Schmid, Boehringer Ingelheim, Germany
- Katja Rybakova, Vrije Universiteit, Amsterdam, The Netherlands
- Andreas Hoppe, Charite, Berlin, Germany
- Saitou Ryuuta, Mitsubishi Tanabe Pharma Corporation, Japan
- Mats Kvarnstrom, Fraunhofer-Chalmers Centre, Gothenburg, Sweden
- Mats Jirstrand, Fraunhofer-Chalmers Centre, Gothenburg, Sweden
- Catherine Lloyd, Auckland Bioengineering Institute, New Zealand
- Peter Hunter, Auckland Bioengineering Institute, New Zealand
- Andriani Daskalaki, MPI MG, Berlin, Germany
- Harry van Steeg, RIVM, Bilthoven, The Netherlands
- Mirjam Luijten, RIVM, Bilthoven, The Netherlands
- Laxmann Yetukuri, VTT Technical Research Centre of Finland
- Antoine Soubret, Novartis Pharma AG, Modeling & Simulation, Basel, Switzerland
- Rune Kleppe, University of Bergen, Norway
- Jean Hausser, University of Basel, Switzerland